Nanoparticle-mediated thermal Cancer therapies: Strategies to improve clinical translatability

M Bravo; B Fortuni; P Mulvaney; J Hofkens; H Uji-i; S Rocha; JA Hutchison

Journal article

Nanoparticle-mediated thermal Cancer therapies: Strategies to improve clinical translatability

M Bravo, B Fortuni, P Mulvaney, J Hofkens, H Uji-i, S Rocha, JA Hutchison

Journal of Controlled Release | Published : 2024

DOI: 10.1016/j.jconrel.2024.06.055

Abstract

Despite significant advances, cancer remains a leading global cause of death. Current therapies often fail due to incomplete tumor removal and nonspecific targeting, spurring interest in alternative treatments. Hyperthermia, which uses elevated temperatures to kill cancer cells or boost their sensitivity to radio/chemotherapy, has emerged as a promising alternative. Recent advancements employ nanoparticles (NPs) as heat mediators for selective cancer cell destruction, minimizing damage to healthy tissues. This approach, known as NP hyperthermia, falls into two categories: photothermal therapies (PTT) and magnetothermal therapies (MTT). PTT utilizes NPs that convert light to heat, while MTT u..

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University of Melbourne Researchers

Paul Mulvaney Author

James Hutchison Author

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Grants

Awarded by Melbourne University

Awarded by Australian Government through the Australian Research Council (ARC) Centre of Excellence in Exciton Science

Awarded by ARC Future Fellowship

Awarded by Research Foundation of Flanders (FWO)

Awarded by KU Leuven

Funding Acknowledgements

The authors are thankful to the Global PhD partnership program between KU Leuven and Melbourne University (GPUM/21/025) . MB, PM, and JAH thank the Australian Government for funding through the Australian Research Council (ARC) Centre of Excellence in Exciton Science (CE170100026) . JAH acknowledges award of an ARC Future Fellowship (FT180100295) . JH, HU, BF and SR acknowledged the financial support from Research Foundation of Flanders (FWO) research grants (G0D4519N, G081916N, VS08523N, G0C1821N) , postdoctoral fellowship (for BF, 12X1419N and 12X1423N) , and from the KU Leuven (C14/15/053, C14/19/079, C14/22/085) . J.H. acknowledges support of the Max Planck Institute (MPI) as a fellow.